Protocol group

medication-diabetes

55 protocols · 162 outcomes with evidence

Subgroups

insulin metformin semaglutide tirzepatide

Protocols (55)

Outcomes & scoring

activity-exercise-tolerance-worsening-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-30	30	1

anxiety-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-low-dose-metformin-dual	-20	25	1

body-composition-weight-change-from-baseline-kilograms-measured2 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	+50	30	1
medication-diabetes-insulin-degludec-tresiba-low-dose-metformin-high-dose-triple	+15	25	1

body-composition-weight-change-from-baseline-measured-pounds1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	+60	30	1

body-composition-weight-change-from-baseline-pounds-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-retatrutide-weekly-protocol	+80	25	1

body-composition-weight-decrease-from-baseline-at-least-37-pounds-binary-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-dose-titrate-dulaglutide-metformin-diet	+60	25	1

body-composition-weight-decrease-rate-pounds-per-week-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-tirzepatide-split-dose-six-day-generic	+20	15	1

body-composition-weight-decrease-total-pounds-self-reported3 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-tirzepatide-weekly	+70	35	1
medication-diabetes-tirzepatide-weekly-dose-escalation-low-start-generic	+40	30	1
medication-diabetes-tirzepatide-weekly-dose-escalation-metformin-taper-generic	+60	40	1

body-composition-weight-increase-from-baseline-at-least-15-pounds-binary-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-30	35	1

body-composition-weight-increase-from-baseline-at-least-25-pounds-binary-measured2 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-very-high-dose-generic	-40	30	1
medication-diabetes-insulin-degludec-tresiba-very-high-dose-morning-generic	-40	30	1

body-composition-weight-increase-from-baseline-at-least-3-pounds-binary-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-low-dose-basal	-10	30	1

body-composition-weight-increase-from-baseline-at-least-30-pounds-binary-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-liraglutide-dual	-50	25	1

body-composition-weight-kilograms-increase-from-baseline-measured3 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-30	30	1
medication-diabetes-insulin-degludec-tresiba-liraglutide-dual	-60	25	1
medication-diabetes-insulin-degludec-tresiba-very-high-dose-generic	-50	30	1

body-composition-weight-kilograms-mean-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-metformin-high-dose-escalation-generic	+20	45	6127
medication-diabetes-metformin-moderate-dose-daily	+25	50	1894

body-composition-weight-pounds-increase-from-baseline-measured2 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-20	30	1
medication-diabetes-insulin-degludec-tresiba-generic	-15	20	1

brain-fog-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-20	35	1

cognition-brain-fog-resolved-achieved-binary-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-retatrutide-weekly-protocol	+80	25	1

cognition-dazed-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-30	25	1

gastrointestinal-abdominal-cramping-severity-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-30	30	1

gastrointestinal-abdominal-pain-generalized-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-20	30	1

gastrointestinal-abdominal-pain-stomach-area-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-60	30	1

gastrointestinal-appetite-carbohydrate-cravings-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-high-dose-generic	-15	30	1

gastrointestinal-appetite-disturbance-general-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-30	25	1

gastrointestinal-appetite-hunger-reduction-better-food-choices-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-tirzepatide-split-dose-six-day-generic	+30	15	1

gastrointestinal-appetite-hunger-reduction-day-6-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-tirzepatide-twice-weekly-low-dose-generic	+40	15	1

gastrointestinal-appetite-loss-vomiting-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-low-dose-basal	-20	30	1

gastrointestinal-appetite-overall-change-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-high-dose-generic	-30	35	1

gastrointestinal-bloating-severity-numeric-rating-scale-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-20	30	1

gastrointestinal-diarrhea-episodes-per-day-count-self-reported-measured2 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-30	30	1
medication-diabetes-insulin-degludec-tresiba-liraglutide-dual	-40	25	1

gastrointestinal-diarrhea-severity-perceived-rating-self-reported2 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-40	25	1
medication-diabetes-insulin-degludec-tresiba-liraglutide-dual	-30	25	1

gastrointestinal-dry-mouth-xerostomia-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-20	30	1

gastrointestinal-dyspepsia-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-30	30	1

gastrointestinal-gastroesophageal-reflux-severity-nrs-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-30	30	1

gastrointestinal-nausea-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-30	30	1

glucose-capillary-whole-blood-milligrams-per-deciliter-measured7 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	+50	30	1
medication-diabetes-insulin-degludec-tresiba-glimepiride-metformin-triple	+50	20	1
medication-diabetes-insulin-degludec-tresiba-high-dose-canagliflozin-aspart	+60	35	1
medication-diabetes-insulin-degludec-tresiba-lispro-mealtime	+30	30	1
medication-diabetes-insulin-degludec-tresiba-low-dose-metformin-dual	-30	25	1
medication-diabetes-insulin-degludec-tresiba-low-dose-metformin-high-dose-triple	+25	25	1
medication-diabetes-insulin-degludec-tresiba-very-high-dose-generic	+40	30	1

glucose-cgm-standard-deviation-change-from-baseline-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	+40	30	1

glucose-cgm-time-below-70-milligrams-per-deciliter-percent-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-weekly-icodec-generic	-8	80	290

glucose-cgm-time-in-range-70-to-180-milligrams-per-deciliter-percent-measured2 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-closed-loop-fast-acting-generic	+80	60	1
medication-diabetes-insulin-degludec-tresiba-generic	+50	30	1

glucose-cgm-time-to-return-to-target-range-change-minutes-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-fast-acting-aspart-generic	+15	30	1

glucose-control-overall-perceived-rating-self-reported4 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-dose-titrate	+20	25	1
medication-diabetes-insulin-degludec-tresiba-fast-acting-mealtime	+40	35	1
medication-diabetes-insulin-degludec-tresiba-generic	+30	25	1
medication-diabetes-insulin-long-acting-detemir-basal	+20	25	1

glucose-control-perfect-binary-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-low-dose-basal	+40	35	1

glucose-control-worsening-perceived-rating-self-reported3 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-30	25	1
medication-diabetes-insulin-degludec-tresiba-generic	-60	25	1
medication-diabetes-insulin-degludec-tresiba-high-dose-evening-generic	-20	25	1

glucose-dawn-phenomenon-absence-achieved-binary-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	+30	30	1

glucose-dawn-phenomenon-severity-decrease-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	+20	20	1

glucose-fasting-serum-above-200-milligrams-per-deciliter-detected-binary-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-high-dose-generic	-30	30	1

glucose-fasting-serum-decrease-at-least-10-milligrams-per-deciliter-binary-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-very-high-dose-generic	+10	30	1

glucose-fasting-serum-milligrams-per-deciliter-measured9 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-daily	-70	25	1
medication-diabetes-insulin-degludec-tresiba-generic	-30	25	1
medication-diabetes-insulin-degludec-tresiba-high-dose-generic	-60	35	1
medication-diabetes-insulin-degludec-tresiba-high-dose-metformin-liraglutide	-70	35	1
medication-diabetes-insulin-degludec-tresiba-moderate-dose-generic	-40	30	1
medication-diabetes-metformin-low-dose-twice-daily	+55	30	1
medication-diabetes-metformin-time-restricted-diet-hiit-supplement	+78	25	1
medication-diabetes-tirzepatide-weekly	+75	45	1
medication-diabetes-tirzepatide-weekly-dapagliflozin-diet-lifestyle-generic	+50	20	1
medication-diabetes-tirzepatide-weekly-dose-escalation-low-start-generic	+45	35	1

glucose-fasting-serum-mmol-per-liter-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-switch-premixed-degludec-aspart-generic	+20	55	47

glucose-fasting-serum-morning-range-100-to-116-milligrams-per-deciliter-at-target-binary-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-dose-titrate-dulaglutide-metformin-diet	+50	25	1

glucose-fasting-serum-overnight-range-80-to-100-milligrams-per-deciliter-target-achieved-binary-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	+40	25	1

glucose-fasting-serum-range-100-to-125-milligrams-per-deciliter-target-achieved-binary-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-high-dose-canagliflozin-aspart	+40	35	1

glucose-fasting-serum-range-low-100s-milligrams-per-deciliter-at-target-binary-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-evening-low-dose-metformin-carbohydrate-low	+60	25	1

glucose-fasting-serum-range-low-100s-milligrams-per-deciliter-target-achieved-binary-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	+40	30	1

glucose-glycated-hemoglobin-a1c-serum-above-16-to-below-8-percent-binary-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-liraglutide-dual	+70	25	1

glucose-glycated-hemoglobin-a1c-serum-decrease-from-baseline-percentage-points-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-glimepiride-metformin-triple	+50	25	1

glucose-glycated-hemoglobin-a1c-serum-mmol-per-mol-measured9 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	+50	30	1
medication-diabetes-insulin-degludec-tresiba-daily	-50	25	1
medication-diabetes-insulin-degludec-tresiba-generic	+50	30	1
medication-diabetes-insulin-multiple-daily-injection-generic	+90	25	1
medication-diabetes-insulin-pump-continuous-subcutaneous	+45	25	1
medication-diabetes-metformin-high-dose-escalation-generic	+30	45	6823
medication-diabetes-metformin-low-dose-twice-daily	+50	30	1
medication-diabetes-metformin-moderate-dose-daily	+35	50	2169
medication-diabetes-metformin-time-restricted-diet-hiit-supplement	+72	25	1
medication-diabetes-prednisone-taper-tirzepatide-initiate	+90	15	1
medication-diabetes-semaglutide-weekly-generic	+85	25	1

glucose-glycated-hemoglobin-a1c-serum-percent-measured12 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-closed-loop-fast-acting-generic	+70	60	1
medication-diabetes-insulin-degludec-aspart-daily-generic	+48	75	582
medication-diabetes-insulin-degludec-daily	+68	85	292
medication-diabetes-insulin-degludec-tresiba-generic	+50	30	1
medication-diabetes-insulin-degludec-tresiba-liraglutide-dual	+70	30	1
medication-diabetes-insulin-fast-acting-bolus-before-meal-generic	+15	30	1
medication-diabetes-insulin-switch-premixed-degludec-aspart-generic	+35	55	78
medication-diabetes-insulin-weekly-icodec-aspart-generic	+45	75	582
medication-diabetes-insulin-weekly-icodec-generic	+65	85	290
medication-diabetes-tirzepatide-weekly	+85	40	1
medication-diabetes-tirzepatide-weekly-dose-escalation	+45	40	1
medication-diabetes-tirzepatide-weekly-dose-escalation-low-start-generic	+40	40	1
medication-diabetes-tirzepatide-weekly-dose-escalation-metformin-taper-generic	+85	45	1
medication-diabetes-tirzepatide-weekly-xigduo-glipizide-triple-generic	+60	35	1

glucose-hyperglycemia-episodes-per-week-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-30	20	1

glucose-hyperglycemia-frequency-decrease-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	+40	30	1

glucose-hyperglycemia-severe-episodes-per-week-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-70	25	1

glucose-hypoglycemia-absent-binary-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-long-acting-evening-separate-fast-acting-generic	+70	25	1

glucose-hypoglycemia-episodes-frequency-decrease-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	+40	25	1

glucose-hypoglycemia-episodes-per-week-self-reported3 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-dose-reduced	+20	25	1
medication-diabetes-insulin-degludec-tresiba-dose-titrate	+50	25	1
medication-diabetes-insulin-degludec-tresiba-generic	-40	20	1

glucose-hypoglycemia-fear-severity-decrease-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	+20	25	1

glucose-hypoglycemia-fear-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	+40	30	1

glucose-hypoglycemia-hyperglycemia-frequency-combined-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-30	35	1

glucose-hypoglycemia-level-1-to-2-episodes-per-week-count-self-reported2 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-aspart-daily-generic	-12	75	582
medication-diabetes-insulin-weekly-icodec-aspart-generic	-25	75	582
medication-diabetes-tirzepatide-weekly-protein-shake-meal-replace-generic	-30	15	1

glucose-hypoglycemia-near-syncope-detected-binary-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-mixed-fast-long-bedtime-generic	-80	20	1

glucose-hypoglycemia-nocturnal-detected-binary-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-40	25	1

glucose-hypoglycemia-nocturnal-severity-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-50	35	1

glucose-hypoglycemia-overnight-episodes-frequency-decrease-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	+60	25	1

glucose-hypoglycemia-severe-episodes-per-week-count-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-daily	0	80	292
medication-diabetes-insulin-weekly-icodec-generic	-10	82	290

glucose-hypoglycemia-severe-nocturnal-occurrence-binary-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-60	25	1

glucose-hypoglycemia-severe-occurrence-binary-self-reported2 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-fast-acting-mealtime	-30	30	1
medication-diabetes-insulin-degludec-tresiba-generic	-70	25	1

glucose-hypoglycemia-severity-decrease-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	+40	25	1

glucose-insulin-carbohydrate-ratio-improvement-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	+50	25	1

glucose-insulin-resistance-homa-ir-improvement-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-tirzepatide-weekly	+55	30	1

glucose-level-overall-increase-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-20	35	1

glucose-lowering-efficacy-improvement-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-very-high-dose-generic	+30	30	1

glucose-mean-serum-change-from-baseline-milligrams-per-deciliter-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-30	35	1

glucose-mean-serum-milligrams-per-deciliter-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	+40	30	1

glucose-medication-insulin-basal-dose-change-units-per-day-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	+60	25	1

glucose-medication-insulin-degludec-dose-units-per-kilogram-body-weight-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-switch-premixed-degludec-aspart-low-ratio	-20	60	66
medication-diabetes-insulin-switch-premixed-degludec-aspart-mid-ratio	+30	50	22

glucose-medication-insulin-injections-per-day-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-switch-premixed-degludec-aspart-generic	+30	55	99

glucose-medication-insulin-long-acting-dose-decrease-percent-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-tirzepatide-weekly	+60	35	1

glucose-medication-insulin-onset-delay-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-30	25	1

glucose-medication-insulin-short-acting-discontinued-binary-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-tirzepatide-weekly	+70	40	1

glucose-medication-insulin-total-daily-dose-units-per-kilogram-body-weight-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-switch-premixed-degludec-aspart-generic	+25	60	88

glucose-medication-oral-other-discontinued-count-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-tirzepatide-weekly-dose-escalation-metformin-taper-generic	+80	40	1

glucose-postprandial-serum-above-200-milligrams-per-deciliter-binary-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-very-high-dose-morning-generic	-20	30	1

glucose-postprandial-serum-mmol-per-liter-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-switch-premixed-degludec-aspart-generic	+25	55	47

glucose-postprandial-serum-peak-concentration-mmol-per-liter-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-closed-loop-fast-acting-generic	+50	60	1

glucose-postprandial-serum-spike-amplitude-milligrams-per-deciliter-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-fast-acting-bolus-before-meal-generic	+15	20	1

glucose-postprandial-spike-frequency-decrease-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	+20	25	1

glucose-stability-nighttime-improvement-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	+30	25	1

glucose-stability-overall-improvement-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	+40	25	1

glucose-stability-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	+30	30	1

glucose-variability-excursion-magnitude-mean-milligrams-per-deciliter-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-fast-acting-aspart-generic	+15	30	1

glucose-variability-overall-decrease-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	+40	25	1

glucose-variability-overall-increase-rating-self-reported3 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-30	35	1
medication-diabetes-insulin-degludec-tresiba-fast-acting-mealtime	-20	30	1
medication-diabetes-insulin-degludec-tresiba-generic	-60	25	1

infection-respiratory-episodes-per-year-count-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-20	25	1

infection-respiratory-occurrence-detected-binary-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-40	30	1

infection-urinary-tract-detected-binary-self-reported3 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-25	25	1
medication-diabetes-insulin-degludec-tresiba-generic	-40	30	1
medication-diabetes-insulin-degludec-tresiba-liraglutide-dual	-40	25	1

infection-urinary-tract-symptoms-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-25	30	1

medication-efficacy-lack-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-tirzepatide-split-dose-weekly-generic	0	15	1

mood-attention-deficit-severity-decrease-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-20	25	1

mood-depression-sadness-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-20	25	1

mood-overall-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	+20	30	1

mood-psychosis-hallucination-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-50	25	1

mood-sadness-and-anxiety-decrease-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-tirzepatide-dose-lower-frequency-reduced-generic	+40	15	1

oncology-celiac-disease-diagnosis-confirmed-achieved-binary-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-80	20	1

pain-ear-congestion-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-low-dose-metformin-dual	-20	25	1

pain-headache-migraine-debilitating-pain-present-binary-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-low-dose-basal	-40	35	1

pain-headache-migraine-pain-severity-nrs-self-reported2 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-40	30	1
medication-diabetes-insulin-degludec-tresiba-low-dose-metformin-dual	-30	25	1

pain-injection-site-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	+30	30	1

pain-musculoskeletal-body-ache-severity-nrs-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-30	25	1

pain-musculoskeletal-joint-pain-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-liraglutide-dual	-30	25	1

pain-musculoskeletal-leg-severity-numeric-rating-scale-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-40	25	1

pain-musculoskeletal-thumb-joint-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-20	30	1

pain-paresthesia-numbness-severity-decrease-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-30	25	1

pain-paresthesia-tingling-severity-numeric-rating-scale-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-30	25	1

qol-deterioration-detected-binary-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-20	30	1

qol-overall-effectiveness-improvement-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-tirzepatide-split-dose-six-day-generic	+15	15	1
medication-diabetes-tirzepatide-split-dose-weekly-generic	+15	15	1

qol-wellbeing-improvement-perceived-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-tirzepatide-split-dose-six-day-generic	+15	15	1

qol-wellbeing-overall-improvement-perceived-rating-self-reported2 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	+20	25	1
medication-diabetes-insulin-degludec-tresiba-fast-acting-mealtime	+20	25	1

qol-wellbeing-overall-perceived-rating-self-reported2 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	+30	30	1
medication-diabetes-insulin-degludec-tresiba-low-dose-metformin-high-dose-triple	+15	25	1

respiratory-cough-severity-nrs-self-reported2 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-20	30	1
medication-diabetes-insulin-degludec-tresiba-very-high-dose-generic	-30	25	1

respiratory-dyspnea-severity-perceived-rating-self-reported2 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-40	25	1
medication-diabetes-insulin-degludec-tresiba-low-dose-metformin-dual	-30	25	1

respiratory-laryngitis-cough-phlegm-composite-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-very-high-dose-generic	-25	30	1

respiratory-laryngitis-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-very-high-dose-generic	-30	25	1

respiratory-phlegm-production-severity-perceived-rating-self-reported2 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-lispro-mealtime	-40	25	1
medication-diabetes-insulin-degludec-tresiba-very-high-dose-generic	-20	25	1

respiratory-problems-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-30	25	1

respiratory-pulmonary-edema-occurrence-detected-binary-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-70	25	1

safety-side-effects-elimination-achieved-binary-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-tirzepatide-twice-weekly-low-dose-generic	+50	15	1

skin-pruritus-injection-site-local-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-10	25	1

skin-pruritus-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-low-dose-metformin-dual	-20	25	1

skin-urticaria-hives-occurrence-any-detected-binary-self-reported2 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-10	30	1
medication-diabetes-insulin-degludec-tresiba-generic	-20	20	1

sleep-disturbance-glycemic-management-related-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-20	30	1

sleep-nocturia-episodes-per-night-change-from-baseline-count-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-20	25	1

symptom-edema-foot-swelling-peripheral-severity-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-50	25	1

symptom-edema-lower-extremity-severity-nrs-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-25	35	1

symptom-malaise-flu-like-severity-perceived-rating-self-reported2 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-20	35	1
medication-diabetes-insulin-degludec-tresiba-generic	-30	30	1

symptom-malaise-general-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-50	25	1

symptom-thirst-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-20	30	1

vestibular-dizziness-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-30	25	1

vision-blurred-severity-nrs-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-20	30	1

vision-disturbance-severity-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-50	25	1

vitality-fatigue-energy-level-deterioration-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-20	30	1

vitality-fatigue-energy-level-increase-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	+20	25	1

vitality-fatigue-energy-level-nrs-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	+30	30	1

vitality-fatigue-energy-morning-improvement-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-retatrutide-weekly-protocol	+70	25	1

vitality-fatigue-severity-decrease-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-retatrutide-weekly-protocol	+70	25	1

vitality-fatigue-severity-perceived-rating-self-reported3 evidence rows

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-50	30	1
medication-diabetes-insulin-degludec-tresiba-low-dose-metformin-dual	-30	25	1
medication-diabetes-semaglutide-weekly-processed-sugar-elimination	0	15	1

vitals-blood-pressure-hypotension-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-20	25	1

vitals-blood-pressure-systolic-change-from-baseline-millimeters-of-mercury-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-basal-only	-40	35	1

vitals-blood-pressure-systolic-millimeters-of-mercury-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-20	20	1

vitals-body-temperature-chills-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-20	30	1

vitals-cardiac-heart-failure-occurrence-detected-binary-measured1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-lispro-mealtime	-80	20	1

vitals-cardiac-palpitations-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-30	25	1

vitals-vasomotor-hot-flash-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-30	25	1

vitals-vasomotor-hyperhidrosis-severity-perceived-rating-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	-20	25	1

vitals-vasomotor-night-sweats-absence-achieved-binary-self-reported1 evidence row

Protocol	Effect	Confidence	N
medication-diabetes-insulin-degludec-tresiba-generic	+30	25	1

Path: medication › diabetes