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Cold exposure attenuates inflammation in metabolic syndrome
RCT showing 10 days of cold acclimation (6°C for 2 hours daily) reduced inflammatory markers (TNF-α, IL-6) by 20-30% in adults with metabolic syndrome.
Anti-inflammatory Effects
- TNF-α: 22% reduction
- IL-6: 28% reduction
- CRP: 15% reduction
Mechanism
Cold-induced activation of BAT and IL-6-mediated anti-inflammatory pathway.
Outcomes
- TNF-α (Tumor Necrosis Factor Alpha)-22
- Interleukin-6-28
- C-Reactive Protein-15