Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease
Randomised pilot (n=100 healthy US adults) of three 5-day fasting-mimicking diet (FMD) cycles versus control: reductions in body weight, trunk/total body fat, blood pressure, and IGF-1; post hoc suggests larger marker shifts in participants classified at higher baseline risk.
Design
- Randomised pilot; 100 generally healthy US adults
- Intervention: 3 cycles of a 5-day FMD (low calories/sugars/protein; higher unsaturated fat) vs control diet
- Primary readouts (trial narrative): weight / adiposity distribution, BP, IGF-1, and other cardiometabolic markers
Reported directional outcomes (abstract)
After 3 months, 3 FMD cycles associated with reductions in body weight, trunk and total body fat, blood pressure, and IGF-1 versus control.
Post hoc / subgroup framing
Authors report that BMI, BP, fasting glucose, IGF-1, TG, LDL/TC, and CRP moved more favourably in participants deemed at risk than in those not at risk.
Evidence hygiene
Feasibility / biomarker pilot—not long-term hard clinical endpoint evidence; do not equate with daily time-restricted eating RCTs on time-restricted-eating.
Publication
Wei M, et al. Sci Transl Med. 2017 Feb 15;9(377):eaai8700. PMID 28202779.
Outcomes
- After 3 months, three 5-day FMD cycles vs control: lower body weight, trunk fat, total body fat, blood pressure, and IGF-1 (trial abstract).
- Post hoc: BMI, BP, fasting glucose, IGF-1, triglycerides, LDL/total cholesterol, and CRP improved more in participants classified at higher baseline risk than in lower-risk participants.