HealthProtocols
← All sources

Relationship of sleep duration with the risk of stroke incidence and stroke mortality: an updated systematic review and meta-analysis

Updated dose-response meta-analysis (20 articles; prospective cohorts through Oct 2020): both short and long self-reported sleep associated with higher stroke incidence and stroke mortality, with U-shaped dose-response patterns in pooled models.

Design

  • Synthesis: systematic review + dose-response meta-analysis of prospective cohorts
  • Corpus: 20 articles / 27 reports (15 stroke incidence; 12 stroke mortality)
  • Search: through 20 Oct 2020 (PubMed, Embase, Cochrane, CNKI, Wangfang)

Pooled categorical risks (abstract)

  • Short sleep ↔ stroke incidence: RR 1.33 (95% CI 1.19–1.49)
  • Short sleep ↔ stroke mortality: RR 1.37 (1.16–1.62)
  • Long sleep ↔ stroke incidence: RR 1.71 (1.50–1.95)
  • Long sleep ↔ stroke mortality: RR 2.41 (1.87–3.09)

Dose-response narrative

Authors report U-shaped relationships between sleep duration and stroke endpoints (including sex- and subtype-stratified patterns in the full text).

Evidence hygiene

Self-reported sleep + residual confounding (undiagnosed OSA, mood, medications) common in cohorts—use as risk stratification / hygiene motivation, not deterministic diagnosis.

Publication

Wang H, et al. Sleep Med. 2022 Feb;91:551-562. PMID 35245890.

Outcomes

  • All-Cause Mortality Risk
    Events: /
  • All-Cause Mortality Risk
    Events: /
  • All-Cause Mortality Risk
    Events: /
  • All-Cause Mortality Risk
    Events: /
View original paper →