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Evaluating the effects of dietary patterns on circulating C-reactive protein levels in the general adult population: an umbrella review of meta-analyses of interventional and observational studies
Umbrella review (27 articles, 30 meta-analyses) recomputing random-effects summaries: among RCT-derived dietary-pattern signals, Mediterranean-style diets ranked strongest for lowering circulating CRP versus other named patterns, but certainty remained weak.
Design
- Umbrella review with random-effects re-pooling of eligible meta-analyses
- Databases: PubMed, Scopus, Epistemonikos through Nov 2023
- PROSPERO: CRD42023484917
Headline (abstract narrative)
Across recomputed RCT strata, Mediterranean diets showed the largest CRP-lowering signal versus other named patterns, followed by vegetarian/vegan and energy-restricted diets—authors grade overall evidence weak.
- Intermittent fasting, ketogenic, Nordic, and Paleolithic patterns did not show consistent inverse associations with CRP in the abstract framing.
Evidence hygiene
Umbrella-of-meta-analyses tier—numeric MDs live in underlying MA PDFs; use this row to tier inflammation narratives, not to replace PREDIMED/DASH event trials.
Publication
Tran DQ, Nguyen Di K, Quynh Chi VT, et al. Br J Nutr. 2024 Sep 28;132(6):783–793. Epub 2024 Oct 4. PMID 39364652.
Outcomes
- C-Reactive ProteinUmbrella recomputation: Mediterranean diet had strongest RCT-aligned signal for lowering circulating CRP versus other named dietary patterns; evidence graded weak in abstract.
- Interleukin-6Abstract contrasts IF/keto/Nordic/Paleo patterns without consistent inverse CRP associations versus Mediterranean/vegetarian/energy-restriction tiers—read underlying MA tables for endpoint-specific MDs.