← All sources
NAD+ metabolism and cellular aging
Foundational review explaining how NAD+ decline with age impairs sirtuin function, mitochondrial respiration, and DNA repair, with implications for longevity interventions.
NAD+ Decline
- 50% decline by age 50
- Impairs sirtuin activity
- Reduces DNA repair capacity
Intervention Targets
NAD+ precursors (NR, NMN) restore cellular NAD+ and sirtuin function.
Outcomes
- NAD+ Level-50