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Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans
Randomized double-blind placebo-controlled crossover (n=13) of 6 weeks NR 1000 mg/day in healthy adults with overweight/obesity: modest increase in fat-free mass percentage and sleeping metabolic rate plus elevated muscle acetylcarnitine handling, but no change in clamp-derived insulin sensitivity or ex vivo mitochondrial respiration.
Design
- Crossover RCT: 6 wk NR (1000 mg/d) vs 6 wk placebo with washout (4–7 wk) between periods (n = 13 completers)
- Phenotyping: hyperinsulinemic-euglycemic clamp, MRS, muscle biopsy, sleeping metabolic rate (SMR)
Positive signals (abstract)
- Fat-free mass %: +1.34% absolute change vs placebo pattern (p = 0.02)
- SMR: increased on NR (p reported)
- Muscle acetylcarnitine and exercise-induced acetylcarnitine formation capacity: higher on NR (p = 0.04 / 0.01)
Null / negative platform findings (abstract)
- Insulin sensitivity (clamp), ex vivo mitochondrial respiration, liver / intramyocellular lipid, BP, inflammatory plasma markers: no significant NR effect
Publication
Remie CME, et al. Am J Clin Nutr. 2020 Jun 1;111(6):1226-1241. PMID 32320006.
Outcomes
- Body Fat Mass% (Percent Change)
- No significant NR effect on hyperinsulinemic-euglycemic clamp insulin sensitivity, ex vivo skeletal muscle mitochondrial respiratory states, or ambulatory blood pressure (abstract).