N=1 Reports on rapamycin.news

N=1 Self-Experiment Data

Steve_Combi (age 65–75)

• Protocol: Transcutaneous vagus nerve stimulation (tVNS) 3–4×/week
• Before: HRV 40–47 ms
• After: HRV 57+ ms
• Change: +10–17 ms (+24–43%)
• Duration: 3+ yrs
• Device: Morning HRV app

anon56293223

• Protocol: Stopped all polypharmacy (incl. suspected minoxidil) over Christmas 2024
• Before: Elevated RHR / low HRV
• After: RHR −10 bpm; HRV → 120s ms
• Change: −10 bpm RHR / HRV into 120s ms
• Duration: ~3 mo
• Device: Oura Ring

Tam

• Protocol: Rapamycin first week (dose unspecified)
• Before: 60-day Athlytic average
• After: Recovery 30% → 18%; HRV −37% from 60-day avg
• Change: −37% HRV
• Duration: First week
• Device: Apple Watch / Athlytic

Neo (age 46)

• Protocol: Zone 2 + resistance training + daily mindfulness + Pulsetto VNS (near-daily) + massage chair 2×/wk
• Before: HRV 30s–40s ms
• After: HRV high 50s–low 60s ms
• Change: +20–30 ms over months
• Duration: Several mo
• Device: WHOOP 4.0 + Oura Ring (dual)