N=1 Reports on rapamycin.news

N=1 Self-Experiment Data

Tomnook (age 69M)

• Protocol: Rapamycin 1mg escalating to 6mg over 5 weeks + indoor rowing 20 min/day
• Before: HRV 20–40 ms; occasional spikes >100 ms
• After: HRV −15% overall; RHR +2–3 bpm; BP 115/73 → 120/75
• Change: −15% HRV / +2–3 bpm
• Duration: 5 wks
• Device: Apple Watch + Oura + 24h BP + CGM

Texasgirl

• Protocol: Rapamycin 2mg + GFJ weekly (or 4mg + GFJ biweekly). Uses wearable to time next dose
• Before: Baseline: RHR high 50s / HRV 20 ms
• After: Post-dose: RHR mid 60s / HRV 12–14 ms; returns to baseline within days
• Change: −6–8 ms HRV / +7–8 bpm RHR per cycle
• Duration: Ongoing; dozens of cycles
• Device: Oura Ring

Newbalance

• Protocol: High-glycemic foods at night consistently tracked — compared before/after starting rapamycin to rule it out as variable
• Before: Baseline (normal evenings)
• After: Lower overnight HRV on high-glycemic evenings
• Change: Cyclical HRV suppression correlated with carb load; independent of rapamycin
• Duration: Ongoing observation
• Device: Oura Ring + HRV4Training