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Effect of Time-Restricted Eating on Weight Loss in Adults With Type 2 Diabetes: A Randomized Clinical Trial
Six-month parallel RCT (n=75) in adults with obesity and type 2 diabetes: 8-hour time-restricted eating (12:00–20:00) without calorie counting produced a significant percent weight reduction vs control (−3.56%; 95% CI −5.92 to −1.20; P = 0.004), whereas prescribed 25% calorie restriction did not reach significance vs control for the same endpoint; HbA1c fell similarly with TRE and calorie restriction vs control with no between-arm glycemic difference.
Design
- Population: adults with obesity and type 2 diabetes (n = 75; intention-to-treat analysis)
- Arms: 8-hour TRE (12:00–20:00, ad libitum within window, no calorie counting) vs 25% calorie restriction (CR) vs control
- Primary endpoint: percent change in body weight by month 6
Outcomes (abstract)
- Weight (% change vs control at 6 months): TRE −3.56% (95% CI −5.92 to −1.20; P = 0.004); CR −1.78% (95% CI −3.67 to 0.11; P = 0.06)
- HbA1c vs control: TRE −0.91% (95% CI −1.61 to −0.20); CR −0.94% (95% CI −1.59 to −0.30) — no significant TRE vs CR separation emphasized in abstract conclusions
- Safety: no serious adverse events reported in abstract summary
Evidence hygiene
- Evening-biased window; not isocaloric feeding-lab factorial designs—compare cautiously to early TRE trials.
- Small n and single-center context; authors call for larger, longer RCTs.
Publication
Pavlou V, Cienfuegos S, Lin S, et al. JAMA Netw Open. 2023 Oct 2;6(10):e2339337. doi: 10.1001/jamanetworkopen.2023.39337. PMID 37889487. ClinicalTrials.gov NCT05225337.
Outcomes
- Six-month percent weight change vs control: time-restricted eating −3.56% (95% CI −5.92 to −1.20; P = 0.004); calorie restriction −1.78% (95% CI −3.67 to 0.11; P = 0.06) per abstract.
- HbA1c (Glycated Hemoglobin)-0.91% (Absolute Change)