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An updated systematic review and meta-analysis on adherence to mediterranean diet and risk of cancer
Updated meta-analysis (117 studies; >3.2 million participants) links highest versus lowest Mediterranean diet adherence to lower pooled cancer mortality (cohort RR 0.87) and lower risks for several site-specific cancers, with NutriGrade ratings mostly low to very low outside a few moderate-certainty comparisons.
Design
Systematic review + random-effects pooling of cohort / observational and available RCT literature through April 2020; NutriGrade certainty reported.
Headline pooled associations (highest vs lowest adherence)
- Cancer mortality (cohorts): RR 0.87 (95% CI 0.82–0.92; N = 18)
- All-cause mortality among cancer survivors (cohorts): RR 0.75 (0.66–0.86; N = 8)
- Colorectal cancer (observational): RR 0.83 (0.76–0.90; N = 17)
Evidence hygiene
Observational adherence scores—confounding by broader healthy behaviours is likely; abstract stresses low / very low NutriGrade for many comparisons.
Publication
Morze J, Danielewicz A, Przybyłowicz W, et al. Eur J Nutr. 2021 Apr;60(3):1561-1586. PMID 32770356.
Outcomes
- All-Cause Mortality RiskEvents: /
- All-Cause Mortality RiskEvents: /