N=1 Data from mcpress.mayoclinic.org

N=1 Self-Experiment Data

Mayo Clinic Press author

• Protocol: 300-day “Optimal Living” coaching: earlier dinner + bedtime routine + wine eliminated + modified exercise
• Before: HRV ~35 ms
• After: HRV mid-40s ms
• Change: +~10 ms (+29%)
• Duration: ~10 mo
• Device: Smart ring (likely Oura)

Mayo Clinic author (mid-protocol)

• Protocol: COVID infection mid-way through 300-day protocol — involuntary within-study illness control
• Before: HRV mid-40s ms (post-optimization)
• After: HRV dropped to teens
• Change: −20+ ms acute (illness)
• Duration: Acute illness episode
• Device: Smart ring