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Intermittent fasting: physiological and molecular mechanisms
Landmark review explaining how intermittent fasting activates cellular stress resistance pathways, enhances mitochondrial function, and improves metabolic flexibility.
Molecular Mechanisms
- Ketone body production increases
- Autophagy upregulated 3-5x
- BDNF expression enhanced
- Insulin/IGF-1 signaling reduced
Metabolic Switching
12-16 hour fast triggers metabolic shift to fat oxidation.
Outcomes
- Autophagy Upregulation3