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Fasting and autophagy: molecular mechanisms
Review explaining how fasting (16-24 hours) activates autophagy through mTOR inhibition, enhancing cellular cleanup and longevity pathways.
Autophagy Activation
- mTOR inhibition begins: 12-16 hours
- Autophagy peaks: 24-48 hours
- Protein synthesis restoration: 24 hours refeeding
Health Benefits
Enhanced cellular quality control, reduced senescent cells, extended healthspan.
Outcomes
- autophagy-timingmTOR inhibition begins at 12-16 hours; autophagy peaks at 24-48 hours of fasting