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Effectiveness of Early Time-Restricted Eating for Weight Loss, Fat Loss, and Cardiometabolic Health in Adults With Obesity: A Randomized Clinical Trial

14-week RCT (n=90) in adults with obesity on energy restriction: early time-restricted eating (7:00–15:00) plus energy restriction produced greater mean weight loss than control eating (≥12 h window) plus energy restriction (−2.3 kg; 95% CI −3.7 to −0.9; P = 0.002); co-primary fat-loss difference did not reach significance in the primary model (P = 0.09), while diastolic blood pressure improved (−4 mmHg; 95% CI −8 to 0; P = 0.04).

Design

  • Population: adults with obesity receiving clinic-based weight-loss treatment (n = 90)
  • Arms: early TRE (8-hour window 07:00–15:00) + energy restriction (ER) vs control eating (≥12 h window) + ER
  • Co-primary outcomes: weight loss and fat loss at 14 weeks

Key outcomes (abstract)

  • Weight: −2.3 kg greater loss with eTRE + ER vs CON + ER (95% CI −3.7 to −0.9; P = 0.002)
  • Fat mass (primary model): −1.4 kg difference (95% CI −2.9 to 0.2; P = 0.09) — not significant at α used for co-primary interpretation in the abstract framing
  • Diastolic BP: −4 mmHg (95% CI −8 to 0; P = 0.04)
  • Mood POMS subscales: fatigue-inertia / vigor-activity / depression-dejection signals summarized as improved with eTRE + ER in the abstract narrative

Evidence hygiene

  • Window-specific early TRE; do not generalize to late-evening 16:8 protocols without reading comparator timing.
  • Interpret alongside 12-month NEJM calorie-matched CR trial (Liu et al. 2022, PMID 35443107) where window + CR did not beat CR alone on weight.

Publication

Jamshed H, Steger FL, Bryan DR, et al. JAMA Intern Med. 2022 Sep 1;182(9):953-962. doi: 10.1001/jamainternmed.2022.3050. PMID 35939311. ClinicalTrials.gov NCT03459703.

Outcomes

  • Greater mean weight loss with early time-restricted eating + energy restriction vs control eating + energy restriction: −2.3 kg (95% CI −3.7 to −0.9; P = 0.002).
  • Diastolic Blood Pressure
    -4
    mmHg (Millimetres of Mercury)
  • Co-primary fat-mass difference −1.4 kg (95% CI −2.9 to 0.2; P = 0.09)—not statistically significant in the primary abstract framing for fat loss.
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