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Effect of changes in potassium intake on blood pressure: a dose-response meta-analysis of randomized clinical trials (2000-2024)
Dose-response meta-analysis of 10 RCTs (2000–2024) using 24-hour urinary potassium excretion: a 50 mmol/day increase associated with about 5.3/3.6 mmHg lower systolic/diastolic BP in hypertensive participants versus minimal shifts in normotensive cohorts.
Design
- SR + dose–response MA of RCTs (Jan 2000 – Apr 2024)
- Exposure metric: 24 h urinary potassium differences (supplementation arms)
- Models: linear, quadratic, one-stage cubic spline; subgroups with vs without hypertension
Dose headline (50 mmol/day urinary K increase; abstract)
- Normotensive: SBP ~−0.5 mmHg, DBP ~−0.12 mmHg
- Hypertensive: SBP ~−5.3 mmHg, DBP ~−3.62 mmHg
Evidence hygiene
Only 10 RCTs pooled—authors caution on sparse evidence; hyperkalemia risk and CKD context are not the same as free-living DASH feeding studies.
Publication
Granal M, Sourd V, et al. Clin Kidney J. 2025 Feb 3;18(3):sfaf173. PMID 40612568.
Outcomes
- Systolic Blood Pressure-5.3mmHg (Millimetres of Mercury)
- Diastolic Blood Pressure-3.62mmHg (Millimetres of Mercury)