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Effect of Moderate to Vigorous Physical Activity on All-Cause Mortality in Middle-aged and Older Australians

Prospective cohort (45 and Up Study; n=204,542; mean age ~45–75 y at baseline): higher volumes of self-reported moderate-to-vigorous activity associated with lower all-cause mortality; among people reporting any MVPA, reporting a larger fraction as vigorous associated with additional mortality benefit.

Design

  • Prospective cohort; 204,542 adults (45–75 y at recruitment) from New South Wales, Australia
  • Exposure: Active Australia Survey–derived MVPA minutes/week and fraction of MVPA reported as vigorous
  • Outcome: all-cause mortality through Jun 2014 (~1.44M person-years; 7,435 deaths)

Dose–response highlights (fully adjusted models in abstract)

  • MVPA vs none: HRs 0.66 (10–149 min/wk), 0.53 (150–299), 0.46 (≥300)
  • Among reporters of any MVPA: some vigorous (<30% of MVPA) HR 0.91 vs none vigorous; ≥30% vigorous HR 0.87 vs none vigorous

Evidence hygiene

  • Self-report activity—misclassification and healthy-responder bias; still useful for vigorous-intensity policy arguments next to lab HIIT trials.

Publication

Gebel K, Ding D, Chey T, Stamatakis E, Brown WJ, Bauman AE. JAMA Intern Med. 2015 Jun;175(6):970-7. PMID 25844882.

Outcomes

  • All-Cause Mortality Risk
    Events: /
  • All-Cause Mortality Risk
    Events: /
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