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DASH diet and blood pressure reduction in adults with and without hypertension: systematic review and meta-analysis

Meta-analysis of 30 randomised trials (n=5545): versus control diets, DASH lowered pooled systolic blood pressure by 3.2 mmHg and diastolic blood pressure by 2.5 mmHg (both P<0.001; GRADE moderate).

Design

  • 30 RCTs, n = 5545
  • Outcomes: difference in mean attained SBP/DBP vs control (random- and fixed-effect models; heterogeneity explored)

Pooled BP deltas vs control

  • SBP: −3.2 mmHg (95% CI −4.2 to −2.3; P < 0.001)
  • DBP: −2.5 mmHg (95% CI −3.5 to −1.5; P < 0.001)
  • GRADE: moderate certainty for both (per abstract)

Subgroup signal (abstract)

Larger SBP reductions when trial mean sodium >2400 mg/d and when mean age <50 y—still interpret with meta-regression caveats.

Publication

Filippou CD, Tsioufis CP, Thomopoulos CG, et al. Adv Nutr. 2020 Sep 1;11(5):1150-1160. PMID 32330233; PROSPERO CRD42019128120.

Outcomes

  • Systolic Blood Pressure
    -3.2
    mmHg (Millimetres of Mercury)
  • Diastolic Blood Pressure
    -2.5
    mmHg (Millimetres of Mercury)
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