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Dose-response associations between accelerometry measured physical activity and sedentary time and all cause mortality: systematic review and harmonised meta-analysis

Individual-participant harmonised meta-analysis of eight cohorts (36,383 adults; 2,149 deaths) links higher accelerometer-measured physical activity (total, light, MVPA) and lower sedentary time to materially lower all-cause mortality in non-linear dose–response models.

Design

  • 8 cohorts, 36,383 participants, 2,149 deaths (median FU 5.8 y)
  • Hip accelerometry for sedentary time, light PA, MVPA, and total PA

Illustrative quarter HRs (all-cause mortality)

  • Total PA: 1.00 / 0.48 / 0.34 / 0.27 (least → most active quarters)
  • Light PA: 1.00 / 0.60 / 0.44 / 0.38
  • MVPA: 1.00 / 0.64 / 0.55 / 0.52
  • Sedentary time: 1.00 / 1.28 / 1.71 / 2.63 (least → most sedentary quarters)

Evidence hygiene

Prospective observational—residual confounding possible despite rich covariate adjustment; sedentary HRs are not intervention proof for standing desks by themselves.

Publication

Ekelund U, Tarp J, Fagerland MW, et al. BMJ. 2019 Aug 21;366:l4570. PMID 31434697.

Outcomes

  • All-Cause Mortality Risk
    Events: /
  • All-Cause Mortality Risk
    Events: /
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